The United States and the Central Asian nations reaffirmed their commitment to expanding cooperation during the C5+1 Ministerial held in Samarkand, Uzbekistan, on Monday (19 Oct).

Foreign ministers from Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan, alongside US Secretary of State Marco Rubio, outlined plans to strengthen partnerships focused on economic connectivity, security, energy and emerging technologies.

Key developments:

  • The countries pledged to strengthen the Trans-Caspian Trade Route through improved infrastructure, trade links and regional integration.
  • Cooperation will expand in energy, critical minerals, technology and digital connectivity to support economic growth and supply chain resilience.
  • The partnership will focus on counterterrorism, cybersecurity, border security and nuclear security cooperation.
  • Uzbekistan signed the Artemis Accords, expanding cooperation with the United States on peaceful and transparent space exploration.

The C5+1 platform, established more than a decade ago, reflects growing US engagement with Central Asia as the region seeks a larger role in global trade, connectivity and strategic cooperation.

ℹ️   US Department of State

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US Secretary of State Marco Rubio participates in the C5+1 Ministerial with Uzbekistan’s Foreign Minister Bakhtiyor Saidov, Kazakhstan’s Foreign Minister Mukhtar Tileuberdi, Tajikistan’s Foreign Minister Sirojiddin Muhriddin, Turkmenistan’s Foreign Minister Rashid Meredov, and Kyrgyzstan’s Foreign Minister Jeenbek Kulubayev, at the Congress Center in Samarkand, Uzbekistan, October 19, 2026. REUTERS/Kylie Cooper/Pool
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C5+1 Ministerial highlights expanding US-Central Asia partnership
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